Sunday, 10 June 2012

Allergen Bureau Latest News Update

Advances in coeliac disease research

The recent scientific and clinical advances in coeliac disease research have been summarised in a review published in the journal Current Opinion in Gastroenterology.

Epidemiological studies have shown that coeliac disease is as common in parts of Asia, Africa and Eastern Europe as it is in the Western world. Large population-based studies have expanded knowledge of the long-term risks of coeliac disease, which no longer includes infertility (once a gluten free diet is established), and explored relationships with concomitant autoimmune diseases such as type 1 diabetes and microscopic colitis.

A particularly interesting finding is that vitamin A supplementation can actually worsen the inflammatory response in people with coeliac disease, while there is some evidence to suggest vitamin C may be beneficial.

In terms of advances in coeliac disease treatment, the‘gold-standard’ remains lifelong adherence to a strict gluten-free diet. However, there is continuing work on other therapeutic options including vaccinations, oral enzyme supplements and inhibitors of the gliadin antigen. At the same time, research is being conducted on new varieties of oats and barley that are better tolerated by those sensitive to gluten and new wheat varieties with minimal gliadin content are also being studied. Some work in this field has shown the gliadin content of regular bread can be reduced by 85% while maintaining baking quality.

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